• Image Analysis
  • Single Cell / Single Molecule
  • Technologies for in vivo biology on animal models

Development of a reproducible multiscale correlative microscopy workflow to track fates and functions of individual exosomes in vivo

Industrial partners  CryoCapCell


Exchange of exosomes constitutes original intercellular communication pathways in major physio- pathological processes. Identifying target cells and functions of exosomes in vivo is of prime importance to strengthen our understanding of exosome communication but also for their future use as biomarkers and as therapeutics.

We have unlocked a scientific and technological latch by developing an in vivo model in zebrafish embryos to track individual endogenous exosomes in the whole organism. To further investigate their fates and functions, we propose to set up a reproducible workflow of in vivo dynamic Correlative Light and Electron Microscopy (CLEM) on this animal model. The realization of this project requires significant microscopy and software developments.

Correlating functional and ultrastructural information will help identifying exosome targets and cell biology processes supporting this fundamental mechanism of communication, thus paving the way for exosome clinical application.



As a response to the : Call for projects 2018 : Innovative technologies

Development and Dissemination of Innovative Technologies to be Used in Research in Life Sciences

Details & Selected Projects


  • Endosomal dynamics in neuropathies

    Institute of Psychiatry and Neuroscience of Paris (IPNP)
    University Paris Descartes

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  • Structure and membrane compartments

    CNRS - French National Centre for Scientific Research
    Curie Institute
    Sorbonne University

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  • Space-time Imaging of Organelles and Endomembranes Dynamics

    CNRS - French National Centre for Scientific Research
    Sorbonne University

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