• Microfluidics
  • High Tech / Low Cost Technologies
  • Technologies for in vivo biology on animal models

SYNALGIA – Coupling of microfluidic lab-on-chip to ion-mobility mass spectrometry for Parkinson disease biomarker validation



The recent years have seen a rise of evidences interconnecting protein unfolding and structural pathologies prion and prion-like proteins. These breakthroughs were achieved by using state of the art physico-chemical technologies (mass spectrometer coupled with ion-mobility financed by Ile de France region).

Recently we choose to work on α-synuclein (Parkinson) that shares similar properties with prion protein. In this context we identified a potential biomarker (conformational biomarker) of Parkinson disease. However, before any use of this last as a clinical diagnostic biomarker we must confirm our results both on models (mutants and model animals) and biological samples from patients. In these cases, we will have to deal with extremely complex solutions where α-synuclein must be extracted.

Then the goal of this study is to develop a lab-on-a-chip device that would allow in one step the extraction and purification of our biomarker and its use as a diagnostic of Parkinson disease.



Plate-forme Transcriptome et Epigénome

As a response to the : Call for projects 2019 : Equipment support for the development of innovative technologies to support research in Life Sciences

Call for projets 2019 : Equipment support

Details & Selected Projects


  • Institut de Chimie Physique (LCP)

    CNRS - French National Centre for Scientific Research
    Paris Saclay University

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