• Microfluidics
  • Single Cell / Single Molecule

KaryoDrop – Noninvasive prenatal diagnosis of trisomy 21 based on circulating trophoblastic cells



Down syndrome or trisomy 21 is one of the most common birth defect, caused by a triplicated chromosome 21. To date, amniocentesis is the only 100% reliable test to detect fetal chromosomal abnormalities, but it presents safety concerns.

The ambition of this project is to propose a reliable noninvasive prenatal diagnostic based on rare fetal circulating cells: we will capture these cells based on their size from the mother’s blood, using a validated technology (ISET®), and then encapsulate these cells with one cell per droplet, at most, using droplet-based microfluidics.



dispositif de microfluidique

As a response to the : Call for projects 2019 : Co-development of innovative technologies & methods

Co-development of innovative technologies & methods

Details & Selected Projects


  • Necker-Enfants Malades Institute – Faculté de médecine Paris Descartes

    CNRS - French National Centre for Scientific Research
    University Paris Descartes

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