Breast cancer: Analyzing individual cells for better treatment | End-user application

The fight against cancer is the fundamental mission of the Institut Curie.
Among the teams that are part of this foundation, Silvia Lopez-Lastra (program manager at the Cancer Immunotherapy center) and Amandine Trouchet (manager of the Single Cell platform) are conducting a collaborative research project on specific cells of the immune system: macrophages.

At the interface between physics, chemistry and biology, these researchers are studying the different types of macrophages present in the tumor environment, at the scale of a single cell.

A better understanding of the cells surrounding tumors could enable these researchers to improve the immune response to cancer.

Discover this research project illustrating one of DIM ELICIT’s end-user applications: the study of the “single cell/molecule“!

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We would like to thank :
– Silvia Lopez Lastra, Amandine Trouchet, Eleonora Timperi, Paul Gueguen, Emanuela Romano, Sebastian Amigorena, Andrew Griffiths and all the staff of the Institut Curie and ESPCI who contributed to the film
– the directors and members of the steering committee of the DIM ELICIT
– the Île-de-France Region
– and of course l’Esprit Sorcier !

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This project is initiated by Emanuela Romano and Sebastian Amigorena (Medical Director and Scientific Director of the Cancer Immunotherapy Center), as well as Prof. Andrew Griffiths, Director of the LBC (Laboratory of BioChemistry) team at the Ecole Supérieure de Physique Chimie Industrielles de la Ville de Paris, for the development of the Single Cell technology.

All the results presented here were generated by Eleonora Timperi (post-doctoral student) and, for bioinformatics analysis, Paul Gueguen (PhD student). Medical-scientific studies such as this one, at the interface of fundamental research, clinical research and translational research, are at the heart of the Institut Curie’s establishment project. They require collaborative work between actors from the research center and the Institut Curie Hospital. We would like to thank them as well as the LabEx DCBIOL and the SIRIC.