• Microfluidics
  • High Tech / Low Cost Technologies
  • Organs-on-chips

AutoStemLab – Automated differentiation of human induced pluripotent stem cells and Lab on-a-Chip models for cardiac tissue engineering

Project lead by  Yong Chen,  Onnik Agbulut
Industrial partners  MesoBioTech


We aim to develop a cell culture platform to automatically differentiate human induced pluripotent stem cells (hiPSCs) for lab-on-a chip applications.

This platform will consist of a culture unit, placed in an incubator for the circulation of the culture medium, a cold unit for storing and supplying the medium and cell factors to the circulating loop, and a control unit for accurate and long term regulation.
In vivo-like culture substrate made of monolayer nanofibers and microfluidic circulatory system will be used for organ tissue generation.
Such a platform will be flexible, versatile and compatible but different from conventional tools, which are mostly for 2D and static culture. Here, the medium exchange is impulse perfusion-diffusion based and can be operated automatically and reproducibly at high resolution.

By using this platform, time and efforts will be reduced and both cardiac and alveolar models will be studied for tissue repairing assays.



As a response to the : Call for projects 2018 : Innovative technologies

Development and Dissemination of Innovative Technologies to be Used in Research in Life Sciences

Details & Selected Projects


  • Pole Microfluidics

    CNRS - French National Centre for Scientific Research
    École Normale Supérieure
    Sorbonne University

    Read more
  • Stem cells and biotherapies

    CNRS - French National Centre for Scientific Research
    Institut de Biologie Paris-Seine (IBPS)
    Sorbonne University

    Read more